Ca2+/CalmodulinDependent Protein Kinase II （CaM Kinase II） is a multifunctional calcium and calmodulindependent protein kinase that mediates cellular responses to a wide variety of intercellular signals. CaM Kinase II has been shown to regulate diverse cellular functions including synaptic plasticity, neurotransmitter synthesis and release, gene expression, ion channel function, carbohydrate metabolism, cytoskeletal function, and Ca2+homeostasis. Phosphorylation of Thr286 on the kinase produces an autonomously active form of CaM Kinase II. Autophosphorylation of Thr305 inhibits the activity CaM Kinase II. Phosphorylation at this site appears to reduce the association of CaM Kinase II with the PSD and reduce LTP and learning.
    Calcium/calmodulin-dependent protein kinase II alpha （CaM Kinase II alpha） is a 50 kDa member of CaM Kinase II family of serine-threonine kinases that transduce Ca2+ signals to several target proteins, including ion channels and transcription activators. CaM Kinase II is predominantly expressed in two isoforms in the brain: alpha and beta. CaM Kinase II plays an important role in neuronal plasticity and memory formation, and exerts both calcium-calmodulin-dependent and -independent activities. Autophosphorylation of CaM Kinase II alpha on threonine 286 allows the kinase to switch from a calmodulin-dependent to a calmodulin-independent state, and is required for various cellular functions including hippocampal long-term potentiation （LTP）, special learning, and hippocampus-dependent memory.

Also known as:
alpha CaMKII
Calcium / Calmodulin Dependent Protein Kinase II G
Calcium calmodulin dependent protein kinase CaM kinase II alpha
Calcium calmodulin dependent protein kinase II alpha-B subunit
Calcium calmodulin dependent protein kinase II
Calcium calmodulin dependent protein kinase type II alpha chain
Calcium calmodulin dependent protein kinase type II beta chain
Calcium/calmodulin dependent protein kinase II alpha
Calcium/calmodulin dependent protein kinase type II alpha chain
CaM kinase II alpha chain
CaM kinase II alpha subunit
CaM kinase II beta chain
CaM kinase II beta subunit
CaM kinase II delta chain
CaM kinase II delta subunit
CAM2
CaMK II alpha subunit
CaMK II beta subunit
CaMK II delta subunit
Camk2a
CAMK2B
CAMK2D
CAMKA
CAMKB
KIAA0968
PK2CDD
PKCCD
Proline rich calmodulin dependent protein kinase